プロフィール
学歴・経歴
- 慶應義塾大学 医学部卒
- 慶應義塾大学医学部医学 研究科 博士課程
- 慶應義塾大学病院 精神神経科
- Centre for
Addiction and Mental Health
(トロント大学), Research Fellow - 国立研究開発法人
量子科学技術研究開発機構
資格
- 精神保健指定医
- 日本精神神経学会 専門医
所属学会
- 日本精神神経学会
- 日本うつ病学会
- 日本神経精神薬学会
研究論文（査読有）
詳しくはこちら
- Sano Y, Yamamoto Y, Kubota M, Moriguchi S, Matsuoka K, Kurose S, Tagai K, Endo H, Yamagata B, Suzuki H, Tarumi R, Nomoto K, Takado Y, Kawamura K, Zhang MR, Tabuchi H, Mimura M, Uchida H, Higuchi M, Takahata K. (2024) Alterations of striatal phosphodiesterase 10 A and their association with recurrence rate in bipolar I disorder. Transl Psychiatry. Oct 2;14(1):403. doi: 10.1038/s41398-024-03107-3.
- Hart XM, Gründer G, Ansermot N, Conca A, Corruble E, Crettol S, Cumming P, Hefner G, Frajerman A, Howes O, Jukic MM, Kim E, Kim S, Maniscalco I, Moriguchi S, Müller DJ, Nakajima S, Osugo M, Paulzen M, Ruhe HG, Scherf-Clavel M, Schoretsanitis G, Serretti A, Spina E, Spigset O, Steimer W, Süzen SH, Uchida H, Unterecker S, Vandenberghe F, Verstuyft C, Zernig G, Hiemke C, Eap CB. (2024) Optimisation of pharmacotherapy in psychiatry through therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests: Focus on antipsychotics. World J Biol Psychiatry. Sep 1:1-86. doi: 10.1080/15622975.2024.2366235.
- Bun S, Ito D, Tezuka T, Kubota M, Ueda R, Takahata K, Moriguchi S, Kurose S, Momota Y, Suzuki N, Morimoto A, Hoshino Y, Seki M, Mimura Y, Shikimoto R, Yamamoto Y, Hoshino T, Sato Y, Tabuchi H, Mimura M. (2023) Performance of plasma Aβ42/40, measured using a fully automated immunoassay, across a broad patient population in identifying amyloid status. Alzheimers Res Ther. Sep 4;15(1):149. doi: 10.1186/s13195-023-01296-5.
- Koshimori Y, Cusimano MD, Vieira EL, Rusjan PM, Kish SJ, Vasdev N, Moriguchi S, Boileau I, Chao T, Nasser Z, Ishrat Husain M, Faiz K, Braga J, Meyer JH. (2023) Astrogliosis marker 11C-SL25.1188 PET in traumatic brain injury with persistent symptoms. Brain. Nov 2;146(11):4469-4475. doi: 10.1093/brain/awad279.
- Yamamoto Y, Takahata K, Kubota M, Takeuchi H, Moriguchi S, Sasaki T, Seki C, Endo H, Matsuoka K, Tagai K, Kimura Y, Kurose S, Mimura M, Kawamura K, Zhang MR, Higuchi M. (2023) Association of protein distribution and gene expression revealed by positron emission tomography and postmortem gene expression in the dopaminergic system of the human brain. Eur J Nucl Med Mol Imaging. Nov;50(13):3928-3936. doi: 10.1007/s00259-023-06390-2.
- Horita N, Moriguchi S. (2023) COVID-19, young people, and suicidal behaviour. Lancet Psychiatry. Jul;10(7):484-485. doi: 10.1016/S2215-0366(23)00159-1.
- Kitamura S, Kimura Y, Takahata K, Moriguchi S, Kubota M, Shimada H, Endo H, Takado Y, Kawamura K, Zhang MR, Suhara T, Higuchi M. (2023) Serotonergic Neurotransmission in Limbic Regions May Reflect Therapeutic Response of Depressive Patients: A PET Study With 11C-WAY-100635 and 18F-MPPF. Int J Neuropsychopharmacol. Jul 31;26(7):474-482. doi: 10.1093/ijnp/pyad026.
- Ino H, Honda S, Yamada K, Horita N, Tsugawa S, Yoshida K, Noda Y, Meyer JH, Mimura M, Nakajima S, Moriguchi S. (2023) Glutamatergic Neurometabolite Levels in Bipolar Disorder: A Systematic Review and Meta-analysis of Proton Magnetic Resonance Spectroscopy Studies. Biol Psychiatry Cogn Neurosci Neuroimaging. Feb;8(2):140-150. doi: 10.1016/j.bpsc.2022.09.017.
- Findings of 18 F-PI-2620 tau PET imaging in patients with Alzheimer's disease and healthy controls in relation to the plasma P-tau181 levels in a Japanese sample. Bun S, Moriguchi S, Tezuka T, Sato Y, Takahata K, Seki M, Nakajima S, Yamamoto Y, Sano Y, Suzuki N, Morimoto A, Ueda R, Tabuchi H, Ito D, Mimura M. Neuropsychopharmacol Rep. 2022 Jul 17. doi: 10.1002/npr2.12281. Online ahead of print.
- Trends in Suicide in Japan Following the 2019 Coronavirus Pandemic. Horita N, Moriguchi S. JAMA Netw Open. 2022 Mar 1;5(3):e224739. doi: 10.1001/jamanetworkopen.2022.4739.
- Publication Rate in English of Abstracts Presented at the Annual Meeting of the Japanese Society of Psychiatry and Neurology. : Moriguchi S, Yoshida K(co-first), Koda M, Oka T, Ueno F, Ikai-Tani S, Tani H, Mimura M. Psychiatry Clin Neurosci. 2022 Mar 16:206-211. doi: 10.1111/pcn.13351. Online ahead of print.
- Neuromelanin accumulation in patients with schizophrenia: A systematic review and meta-analysis. Ueno F, Iwata Y, Nakajima S, Caravaggio F, Rubio JM, Horga G, Cassidy CM, Torres-Carmona E, de Luca V, Tsugawa S, Honda S, Moriguchi S, Noda Y, Gerretsen P, Graff-Guerrero A. Neurosci Biobehav Rev. 2021 Oct 27:S0149-7634(21)00468-1. doi: 10.1016/j.neubiorev.2021.10.028.
- Glutamatergic and GABAergic metabolite levels in schizophrenia-spectrum disorders: a meta-analysis of 1H-magnetic resonance spectroscopy studies. Nakahara T, Tsugawa S, Noda Y, Ueno F, Honda S, Kinjo M, Segawa H, Hondo N, Mori Y, Watanabe H, Nakahara K, Yoshida K, Wada M, Tarumi R, Iwata Y, Plitman E, Moriguchi S, de la Fuente-Sandoval C, Uchida H, Mimura M, Graff-Guerrero A, Nakajima S. Mol Psychiatry. 2021 Sep 28. Doi:10.1038/s41380-021-01297-6.
- Dynamic alterations in the central glutamatergic status following food and glucose intake: in vivo multimodal assessments in humans and animal models. Kubota M, Kimura Y, Shimojo M, Takado Y, Duarte JM, Takuwa H, Seki C, Shimada H, Shinotoh H, Takahata K, Kitamura S, Moriguchi S, Tagai K, Obata T, Nakahara J, Tomita Y, Tokunaga M, Maeda J, Kawamura K, Zhang MR, Ichise M, Suhara T, Higuchi M. J Cereb Blood Flow Metab. 2021 Nov;41(11):2928-2943. doi: 10.1177/0271678X211004150. Epub 2021 May 26.
- Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants. Ichikawa N, Lisi G, Yahata N, Okada G, Takamura M, Hashimoto RI, Yamada T, Yamada M, Suhara T, Moriguchi S, Mimura M, Yoshihara Y, Takahashi H, Kasai K, Kato N, Yamawaki S, Seymour B, Kawato M, Morimoto J, Okamoto Y. Sci Rep. 2020 Oct 14;10(1):17650. doi: 10.1038/s41598-020-73436-y.
- Treatment effects on neurometabolite levels in schizophrenia: A meta-analysis dataset of proton magnetic resonance spectroscopy. Kubota M, Moriguchi S, Takahata K, Nakajima S, Horita N. Data Brief. 2020 Jun 16;31:105862. doi: 10.1016/j.dib.2020.105862. eCollection 2020 Aug.
- Moriguchi S, Takahata K, Shimada H, Kubota M, Kitamura S, Kimura Y, Tagai K, Tarumi R, Tabuchi H, Meyer JH, Mimura M, Kawamura K, Zhang MR, Murayama S, Suhara T, Higuchi M. (2020) Excess tau PET ligand retention in elderly patients with major depressive disorder: a PET study. Mol Psychiatry.2021 Oct;26(10):5856-5863.
- Takahata K, Kimura Y, Sahara N, Koga S, Shimada H, Ichise M, Saito F, Moriguchi S, Kitamura S, Kubota M, Umeda S, Niwa F, Mizushima J, Morimoto Y, Funayama M, Tabuchi H, Bieniek KF, Kawamura K, Zhang MR, Dickson DW, Mimura M, Kato M, Suhara T, Higuchi M. (2019) PET-detectable Tau Pathology Correlates With Long-Term Neuropsychiatric Outcomes in Patients With Traumatic Brain Injury. Brain. Oct 1;142(10):3265-3279
- Moriguchi S, Wilson AA, Miler L, Rusjan PM, Vasdev N, Kish SJ, Rajkowska G, Wang J, Bagby M, Mizrahi R, Varughese B, Houle S, Meyer JH. (2019) Monoamine Oxidase B Total Distribution Volume in the Prefrontal Cortex of Major Depressive Disorder: An [11C]SL25.1188 Positron Emission Tomography Study. JAMA Psychiatry. Jun 1;76(6):634-641
- Moriguchi S, Takamiya A, Noda Y, Horita N, Wada M, Tsugawa S, Plitman E, Sano Y, Tarumi R, ElSalhy M, Katayama N, Ogyu K, Miyazaki T, Kishimoto T, Graff-Guerrero A, Meyer JH, Blumberger DM, Daskalakis ZJ, Mimura M, Nakajima S. (2018) Glutamatergic neurometabolite levels in major depressive disorder: a systematic review and meta-analysis of proton magnetic resonance spectroscopy studies. Mol Psychiatry. Jul;24(7):952-964
- Ogyu K, Kubo K, Noda Y, Iwata Y, Tsugawa S, Omura Y, Wada M, Tarumi R, Plitman E, Moriguchi S, Miyazaki T, Uchida H, Graff-Guerrero A, Mimura M, Nakajima S. (2018) Kynurenine pathway in depression: A systematic review and meta-analysis. Neurosci Biobehav Rev. 90:16-25.
- Ishii T, Kimura Y, Ichise M, Takahata K, Kitamura S, Moriguchi S, Kubota M, Zhang MR, Yamada M, Higuchi M, Okubo Y, Suhara T. (2017) Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain. PLoS One. 12(12):e0189318
- Moriguchi S, Takano H, Kimura Y, Nagashima T, Takahata K, Kubota M, Kitamura S, Ishii T, Ichise M, Zhang MR, Shimada H, Mimura M, Meyer JH, Higuchi M, Suhara T. (2017) Occupancy of Norepinephrine Transporter by Duloxetine in Human Brains Measured by Positron Emission Tomography with (S,S)-[18F]FMeNER-D2. Int J Neuropsychopharmacol. 20(12):957-962.
- Kubota M, Nagashima T, Takano H, Kodaka F, Fujiwara H, Takahata K, Moriguchi S, Kimura Y, Higuchi M, Okubo Y, Takahashi H, Ito H, Suhara T. (2017) Affinity States of Striatal Dopamine D2 Receptors in Antipsychotic-Free Patients with Schizophrenia. Int J Neuropsychopharmacol. 20(11):928-935.
- Takahata K, Kimura Y, Seki C, Tokunaga M, Ichise M, Kawamura K, Ono M, Kitamura S, Kubota M, Moriguchi S, Ishii T, Takado Y, Niwa F, Endo H, Nagashima T, Ikoma Y, Zhang MR, Suhara T, Higuchi M. (2017) A human PET study of [11C]HMS011, a potential radioligand for AMPA receptors. EJNMMI Res. 7: 63
- Moriguchi S, Ichise M, Kimura Y, Takahata K, Mimura M, Yamada M, Suhara T. (2017). New quantification method of Norepinephrine transporter in the cortex area in human brain with (S,S)-[18F]FMeNER-D2. J Nucl Med. 58:1140-1145
- Moriguchi S, Yamada M, Takano H, Nagashima T, Takahata K, Yokokawa K, Ito T, Ishii T, Kimura Y, Zhang MR, Mimura M, Suhara T. (2017) Norepinephrine Transporter in Major Depressive Disorder; A PET study. Am J Psychiatry. 174:36-41.
- Kimura Y, Seki C, Ikoma Y, Ichise M, Kawamura K, Takahata K, Moriguchi S, Nagashima T, Ishii T, Kitamura S, Niwa F, Endo H, Yamada M, Higuchi M, Zhang M, Suhara T. (2015). [11C]TASP457, A Novel PET Ligand for Histamine H3 Receptors in Human Brain. Eur J Nucl Med Mol Imaging. 43:1653-63.
- Kocha H, Moriguchi S, Mimura M. (2014). Revisiting the Concept of Late Catatonia. Compr Psychiatry. 55: 1485-1490.
- Moriguchi S, Bies R, Remington G, Suzuki T, Mamo D, Watanabe K, Mimura M, Pollock B, Uchida H. (2013). Estimated Dopamine D2 Receptor Occupancy and Remission in Schizophrenia: Analysis of the CATIE Data. J Clin Psychopharmacol. 33: 682-685
受賞歴
詳しくはこちら
| 2017年 | Clinical Trials Fellowship Award by the American Society of Clinical Psychopharmacology |
|---|---|
| 2017年 | Society of Biological Psychiatry Travel Fellowship Award |
| 2017年 | 米国核医学会SNMMI Alavi–Mandell Award |
| 2018年 | 精神神経学会・精神医学奨励賞 |
| 2020年 | 日本うつ病学会・学会奨励賞 |
| 2021年 | 慶應義塾大学医学部・三四会奨励賞 |
| 2022年 | 日本うつ病学会・下田光造賞 |
| 2016年 | 上原記念生命科学財団Postdoctoral Fellowship Award |
| 2017年 | 米国核医学会SNMMI Wagner-Torizuka Fellowship |
| 2017年 | The NARSAD Young Investigator Award |
| 2017年 | CIHR（カナダ保健研究機構）ポスドク助成 |
| 2020年 | 科研費基盤B |
| 2021年 | 武田薬品・研究助成 |
| 2021年 | アステラス・研究助成 |
| 2024年 | 科研費基盤B |
